The following list is a small selection of a larger and daily growing pool of studies showing how the right light, at the right time, is essential for human health

Light related studies on human health

 

  1. Insufficient Sun Exposure Has Become a Real Public Health Problem
    1. https://pubmed.ncbi.nlm.nih.gov/32668607/
  2. Regular sun exposure benefits health
    1. https://pubmed.ncbi.nlm.nih.gov/27876126/
  3. Avoidance of sun exposure as a risk factor for major causes of death: a competing risk analysis of the Melanoma in Southern Sweden cohort.
    1. https://www.ncbi.nlm.nih.gov/pubmed/26992108
  4. Light at night and modeled circadian disruption predict higher risk of mortality: A prospective study in >88,000 participants
    1. https://www.medrxiv.org/content/10.1101/2023.09.08.23295231v1
  5. Fat cells can sense sunlight—not getting enough increases metabolic syndrome risk
    1. https://www.nexusnewsfeed.com/article/climate-ecology/fat-cells-can-sense-sunlight-not-getting-enough-increases-metabolic-syndrome-risk/
  6. How UV Light Touches the Brain and Endocrine System Through Skin, and Why
    1. https://academic.oup.com/endo/article/159/5/1992/4931051
  7. Timing and Intensity of Light Correlate with Body Weight in Adults
    1. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092251
  8. Biological Effects of Sunlight, Ultraviolet Radiation, Visible Light, Infrared Radiation and Vitamin D for Health
    1. https://ar.iiarjournals.org/content/36/3/1345.long
  9. Risks and benefits of UV radiation in older people: More of a friend than a foe?
    1. https://pubmed.ncbi.nlm.nih.gov/26049767/
  10. Beneficial effects of UV radiation other than via vitamin D production
    1. https://pubmed.ncbi.nlm.nih.gov/22928066/
  11. Mitochondrial Signaling in Mammalian Cells Activated by Red and Near-IR Radiation
    1. https://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2008.00394.x
  12. Study shows how light therapy might help premature babies avoid vision problems
    1. https://medicalxpress.com/news/2019-04-therapy-premature-babies-vision-problems.html
  13. How Daylight Controls the Biological Clock, Organizes Sleep, and Enhances Mood and Performance
    1. https://link.springer.com/chapter/10.1007/978-3-031-04108-2_10
  14. Naturalistic Intensities of Light at Night: A Review of the Potent Effects of Very Dim Light on Circadian Responses and Considerations for Translational Research
    1. https://www.frontiersin.org/articles/10.3389/fneur.2021.625334/full
  15. Solar Ultraviolet Radiation and Breast Cancer Risk: A Systematic Review and Meta-Analysis
    1. https://ehp.niehs.nih.gov/doi/10.1289/EHP4861
  16. Low ultraviolet B and increased risk of brain cancer: an ecological study of 175 countries
    1. https://pubmed.ncbi.nlm.nih.gov/20948235/
  17. Non-image-forming functional roles of OPN3, OPN4 and OPN5 photopigments
    1. https://www.sciencedirect.com/science/article/pii/S2666469023000180
  18. Chromophores and opsins: Physiological processes elicited by visible, ultraviolet and infrared light
    1. https://www.sciencedirect.com/journal/journal-of-photochemistry-and-photobiology/special-issue/104RJ27LSX9
  19. Bright light alters metabolism
    1. https://www.sciencedaily.com/releases/2016/05/160518141416.htm
  20. Day and night light exposure are associated with psychiatric disorders: an objective light study in >85,000 people
    1. https://www.nature.com/articles/s44220-023-00135-8
  21. Lack of interest in sex successfully treated by exposure to bright light
    1. https://www.sciencedaily.com/releases/2016/09/160918214443.htm
  22. Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior
    1. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01013-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124721010135%3Fshowall%3Dtrue
  23. Circadian control of the immune system
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090048/
  24. The Winding Path Towards an Inverse Relationship Between Sun Exposure and All-cause Mortality.
    1. https://www.ncbi.nlm.nih.gov/pubmed/29374755
  25. Skin Exposure to Narrow Band Ultraviolet (UVB) Light Modulates the Human Intestinal Microbiomehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821880/
  26. Comparison of narrowband ultraviolet B exposure and oral vitamin D substitution on serum 25-hydroxyvitamin D concentration.
    1. https://www.ncbi.nlm.nih.gov/pubmed/22512509
  27. Workplace lighting for improving alertness and mood in daytime workers.
    1. https://www.ncbi.nlm.nih.gov/pubmed/29498416
  28. The role of daylight for humans – Gaps in current knowledge
    1. https://www.mdpi.com/2624-5175/2/1/8/htm
  29. Effect of light wavelength on suppression and phase delay of the melatonin rhythm
    1. https://pubmed.ncbi.nlm.nih.gov/11763987/
  30. Differential effects of light wavelength in phase advancing the melatonin rhythm
    1. https://pubmed.ncbi.nlm.nih.gov/14962066/
  31. Sensitivity of the human circadian system to short-wavelength (420-nm) light
    1. https://pubmed.ncbi.nlm.nih.gov/18838601/
  32. Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor
    1. https://pubmed.ncbi.nlm.nih.gov/11487664/
  33. Opsins and mammalian photoentrainment
    1. https://pubmed.ncbi.nlm.nih.gov/12111537/
  34. Circadian rhythms and the blues. AND THE GREENS
    1. https://www.patreon.com/posts/14530810
  35. Circadian Rhythms, Thyroid Hormone and Vision Loss
    1. https://consultqd.clevelandclinic.org/circadian-rhythms-thyroid-hormone-and-vision-loss/?utm_medium=social&utm_source=twitter&utm_campaign=qd+tweets
  36. Solar ultraviolet irradiance and cancer incidence and mortality
    1. https://pubmed.ncbi.nlm.nih.gov/25207360/
  37. Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium
    1. https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0170791
  38. Low ultraviolet B and increased risk of brain cancer: an ecological study of 175 countries
    1. https://pubmed.ncbi.nlm.nih.gov/20948235/
  39. The aging clock and circadian control of metabolism and genome stability
    1. https://www.frontiersin.org/articles/10.3389/fgene.2014.00455/full
  40. UVB Activates Hypothalamic-Pituitary-Adrenal Axis in C57BL/6 Mice
    1. https://pubmed.ncbi.nlm.nih.gov/25317845/
  41. Circadian Rhythms and Mitochondria: Connecting the Dots
    1. https://www.frontiersin.org/articles/10.3389/fgene.2018.00452/full
  42. Sensing the environment: regulation of local and global homeostasis by the skin’s neuroendocrine system
    1. https://pubmed.ncbi.nlm.nih.gov/22894052/
  43. Sunlight and health: shifting the focus from vitamin D3 to photobiomodulation by red and near-infrared light
    1. https://www.sciencedirect.com/science/article/pii/S1568163720302245?s=09
  44. Light harvesting in oxygenic photosynthesis: Structural biology meets spectroscopy
    1. https://science.sciencemag.org/content/369/6506/eaay2058?utm_campaign=SciMag&utm_source=JHubbard&utm_medium=Twitter
  45. 6th Sense: Are We Communicating Using Invisible Light? Biophotons and DNA.
    1. https://medium.com/@michel.kana/6th-sense-are-we-communicating-using-invisible-light-biophotons-and-dna-847c13edae4f
  46. Ultraviolet Radiation Suppresses Obesity and Symptoms of Metabolic Syndrome Independently of Vitamin D in Mice Fed a High-Fat Diet
    1. https://diabetes.diabetesjournals.org/content/63/11/3759
  47. Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284776/
  48. Light-activated neurons deep in the brain control body heat
    1. https://www.nature.com/articles/d41586-020-02481-4?s=09
  49. Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons
    1. https://www.nature.com/articles/s41586-020-2683-0?s=09
  50. Mechanisms involved in enhancing human performance by changing the lighting in the industrial workplace
    1. https://www.sciencedirect.com/science/article/abs/pii/S0169814105000636
  51. Occupational sunlight exposure and melanoma in the U.S. Navy
    1. https://pubmed.ncbi.nlm.nih.gov/2256710/
  52. Sunlight and Vitamin D: Necessary for Public Health
    1. https://www.tandfonline.com/doi/full/10.1080/07315724.2015.1039866
  53. Access to electric light is associated with delays of the dim‐light melatonin onset in a traditionally hunter‐gatherer Toba/Qom community
    1. https://onlinelibrary.wiley.com/doi/abs/10.1111/jpi.12689
  54. The quantum mitochondrion and optimal health
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264502/
  55. Fat cells can sense sunlight—not getting enough increases metabolic syndrome risk
    1. https://phys.org/news/2020-01-fat-cells-sunlightnot-metabolic-syndrome.amp?s=09
  56. Bright Lights, Big Relief – Treating seasonal affective disorder.
    1. https://www.apa.org/research/action/light
  57. ‘Western society is chronically sleep deprived’: the importance of the body’s clock
    1. https://www.theguardian.com/science/2017/oct/06/western-society-is-chronically-sleep-deprived-the-importance-of-the-bodys-clock
  58. Nobel prize for medicine awarded for insights into internal biological clock
    1. https://www.theguardian.com/science/2017/oct/02/nobel-prize-for-medicine-awarded-for-insights-into-internal-biological-clock
  59. Time’s up for daylight saving, say sleep experts
    1. https://www.weforum.org/agenda/2020/09/daylight-saving-time-sleep-health-research/
  60. How artificial light affect our health
    1. https://www.ted.com/talks/dragana_rogulja_how_artificial_light_affects_our_health
  61. Mitochondria as Potential Targets and Initiators of the Blue Light Hazard to the Retina
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721470/
  62. More time outdoors may lower a child’s risk for myopia
    1. https://www.aao.org/eye-health/tips-prevention/children-vision-development
  63. The effects of prior light history on the suppression of melatonin by light in humans
    1. https://onlinelibrary.wiley.com/doi/abs/10.1034/j.1600-079X.2002.01885.x?s=09
  64. Shining a Green Light on a New Preventive Therapy for Migraine
    1. https://uahs.arizona.edu/tomorrow/shining-green-light-new-preventive-therapy-migraine
  65. Cincinnati Children’s: This is Your Brain…on Sunlight
    1. https://www.prnewswire.com/news-releases/cincinnati-childrens-this-is-your-brainon-sunlight-301120800.html?s=09
  66. The risks and benefits of sun exposure 2016
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129901/
  67. Ultraviolet-A light in the treatment of rheumatoid arthritis
    1. https://pubmed.ncbi.nlm.nih.gov/3440328/
  68. The Role of Daylight for Humans: Gaps in Current Knowledge
    1. https://www.mdpi.com/2624-5175/2/1/8/htm
  69. What is light? The visible spectrum and beyond
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763133/
  70. Blue light exacerbates and red light counteracts negative insults to retinal ganglion cells in situ and R28 cells in vitro
    1. https://pubmed.ncbi.nlm.nih.gov/30825600/
  71. Night-time exposure to blue light associated with increased risk of colorectal cancer
    1. https://oncologynews.com.au/night-time-exposure-to-blue-light-associated-with-increased-risk-of-colorectal-cancer/
  72. Saving lives with sunlight | Kevin McGuigan | TEDxDublin
    1. https://www.youtube.com/watch?v=cotBM0laSSo&feature=emb_rel_pause
  73. Sunlight and Your Health: An EnLIGHTening Perspective
    1. https://www.youtube.com/watch?v=oAAlMYWtF_s
  74. Maverick scientist thinks he has discovered a magnetic sixth sense in humans
    1. https://www.sciencemag.org/news/2016/06/maverick-scientist-thinks-he-has-discovered-magnetic-sixth-sense-humans
  75. What Lies at the Heart of Photobiomodulation: Light, Cytochrome C Oxidase, and Nitric Oxide—Review of the Evidence
    1. https://www.liebertpub.com/doi/full/10.1089/photob.2020.4905
  76. Benefits of Sunlight: A Bright Spot for Human Health
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290997/
  77. Effects of near-ultraviolet (UV-A) light on melatonin biosynthesis in vertebrate pineal gland
    1. https://pubmed.ncbi.nlm.nih.gov/10085464/
  78. Physiological and pharmacological perspectives of melatonin
    1. https://pubmed.ncbi.nlm.nih.gov/32520581/
  79. Mitochondrial solar sensitivity: evolutionary and biomedical implications
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154450/
  80. Effect of Light on Human Circadian Physiology
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717723/
  81. Ocular and systemic melatonin and the influence of light exposure
    1. https://onlinelibrary.wiley.com/doi/10.1111/cxo.12824
  82. Lighting and Human Performance
    1. https://www.nap.edu/read/11756/chapter/7
  83. The effects of two different doses of ultraviolet-A light exposure on nitric oxide metabolites and cardiorespiratory outcomes
    1. https://pubmed.ncbi.nlm.nih.gov/29516257/
  84. Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care
    1. https://www.nature.com/articles/s41419-019-1556-7
  85. Effect of wavelength and beam width on penetration in light-tissue interaction using computational methods
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653719/
  86. Mitochondrial cytochrome c oxidase is not the primary acceptor for near infrared light-it is mitochondrial bound water: the principles of low-level light therapy
    1. https://pubmed.ncbi.nlm.nih.gov/31032294/
  87. Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster
    1. https://royalsocietypublishing.org/doi/full/10.1098/rsbl.2015.0073
  88. Aging retinal function is improved by near infrared light (670 nm) that is associated with corrected mitochondrial decline
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364001/
  89. Why We Need More Nature at Work: Effects of Natural Elements and Sunlight on Employee Mental Health and Work Attitudes
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877070/
  90. Tailored lighting intervention improves measures of sleep, depression, and agitation in persons with Alzheimer’s disease and related dementia living in long-term care facilities
    1. https://pubmed.ncbi.nlm.nih.gov/25246779/
  91. Indoor exposure to natural bright light prevents afternoon sleepiness
    1. https://pubmed.ncbi.nlm.nih.gov/16676779/
  92. Narrow-band ultraviolet B radiation induces the expression of β-endorphin in human skin in vivo
    1. https://pubmed.ncbi.nlm.nih.gov/26774381/
  93. The effects of grounding (earthing) on inflammation, the immune response, wound healing, and prevention and treatment of chronic inflammatory and autoimmune diseases
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378297/
  94. Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844808/
  95. Is It Time to Consider Photobiomodulation As a Drug Equivalent?
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643261/pdf/pho.2013.3510.pdf
  96. Skin Exposure to Narrow Band Ultraviolet (UVB) Light Modulates the Human Intestinal Microbiome
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821880/
  97. Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor
    1. https://pubmed.ncbi.nlm.nih.gov/11487664/
  98. Beyond Mitochondria, What Would be the Energy Source of the Cell?
    1. https://www.eurekaselect.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
  99. Daily morning light therapy is associated with an increase in choroidal thickness in healthy young adults
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974399/
  100. Yes, circadian rhythms actually do affect almost everything
    1. https://pubmed.ncbi.nlm.nih.gov/27241553/
  101. Dark matters: effects of light at night on metabolism
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503853/
  102. Mitochondrial cytochrome c oxidase is not the primary acceptor for near infrared light—it is mitochondrial bound water: the principles of low-level light therapy
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462613/
  103. The role of retinal photoreceptors in the regulation of circadian rhythms
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848671/
  104. Metabolic Implications of Exposure to Light at Night: Lessons from Animal and Human Studies
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497102/
  105. A New Threat to Dopamine Neurons: The Downside of Artificial Light
    1. https://www.sciencedirect.com/science/article/abs/pii/S0306452220301408?s=09
  106. Melatonin potentials against viral infections including COVID-19: Current evidence and new findings
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405774/
  107. Sun Exposure and Its Effects on Human Health: Mechanisms through Which Sun Exposure Could Reduce the Risk of Developing Obesity and Cardiometabolic Dysfunction
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086738/
  108. A New Threat to Dopamine Neurons: The Downside of Artificial Light
    1. https://www.sciencedirect.com/science/article/abs/pii/S0306452220301408
  109. Evaluating the Association between Artificial Light-at-Night Exposure and Breast and Prostate Cancer Risk in Spain
    1. https://ehp.niehs.nih.gov/doi/10.1289/ehp1837
  110. Redox Control of the Cell Cycle in Health and Disease
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783918/
  111. The quantum mitochondrion and optimal health
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264502/
  112. Mitochondrial solar sensitivity: evolutionary and biomedical implications
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154450/
  113. Evidence That Homeostatic Sleep Regulation Depends on Ambient Lighting Conditions during Wakefulness
    1. https://www.mdpi.com/2624-5175/1/4/40
  114. Evening home lighting adversely impacts the circadian system and sleep
    1. https://www.nature.com/articles/s41598-020-75622-4
  115. Closing Wounds With Light?
    1. https://kids.frontiersin.org/article/10.3389/frym.2020.539007
  116. The effects of light at night on circadian clocks and metabolism
    1. https://pubmed.ncbi.nlm.nih.gov/24673196/
  117. Harvard university researchers find using Green light reduces stress from Migraines.
    1. https://www.wusa9.com/amp/article/news/health/harvard-researches-find-using-green-light-reduces-stress-from-migraines/65-9ec43df8-fe48-4d0a-b68f-226e86365019?s=09
  118. Dopaminergic modulation of retinal processing from starlight to sunlight
    1. https://pubmed.ncbi.nlm.nih.gov/31109761/
  119. Melatonin Orchestrates Lipid Homeostasis through the Hepatointestinal Circadian Clock and Microbiota during Constant Light Exposure
    1. https://www.mdpi.com/2073-4409/9/2/489/htm
  120. Ultraviolet Radiation Suppresses Obesity and Symptoms of Metabolic Syndrome Independently of Vitamin D in Mice Fed a High-Fat Diet
    1. https://diabetes.diabetesjournals.org/content/63/11/3759
  121. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568574/
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568574/
  122. Melatonin and the Optics of the Human Body
    1. https://www.researchgate.net/publication/331410779_Melatonin_and_the_Optics_of_the_Human_Body
  123. Subcutaneous white adipocytes express a light sensitive signaling pathway mediated via a melanopsin/TRPC channel axis
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703708/
  124. Effets sur la santé humaine et sur l’environnement (faune et flore) des diodes électroluminescentes (LED)
    1. https://www.anses.fr/fr/system/files/AP2014SA0253Ra.pdf
  125. MELANOPSIN AND THE INTRINSICALLY PHOTOSENSITIVE RETINAL GANGLION CELLS: BIOPHYSICS TO BEHAVIOR
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944442/
  126. Intrinsic Photosensitivity Enhances Motility of T Lymphocytes
    1. https://www.nature.com/articles/srep39479
  127. Landmark Study: The Relation of Solar Radiation to Cancer Mortality in North America
    1. https://cancerres.aacrjournals.org/content/76/2/185
  128. “Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859693/
  129. Solar Ultraviolet Radiation and Breast Cancer Risk: A Systematic Review and Meta-Analysis
    1. https://ehp.niehs.nih.gov/doi/10.1289/EHP4861#.X1kB4LPOz1I.twitter
  130. The quantum mitochondrion and optimal health
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264502/
  131. An Hour of Light and Sound a Day Might Keep Alzheimer’s at Bay
    1. https://www.scientificamerican.com/article/an-hour-of-light-and-sound-a-day-might-keep-alzheimers-at-bay/
  132. Physicists Suggest All Matter May Be Made Up of Energy ‘Fragments’
    1. https://www.sciencealert.com/physicists-suggest-energy-fragments-is-the-best-way-to-describe-matter
  133. Blue light exacerbates and red light counteracts negative insults to retinal ganglion cells in situ and R28 cells in vitro
    1. Blue light exacerbates and red light counteracts negative insults to retinal ganglion cells in situ and R28 cells in vitro – ScienceDirect
  134. Out of breath, out of time: interactions between HIF and circadian rhythms
    1. Out of breath, out of time: interactions between HIF and circadian rhythms – PubMed (nih.gov)
  135. UV-LED disinfection of Coronavirus: Wavelength effect
    1. https://www.sciencedirect.com/science/article/pii/S1011134420304942?via%3Dihub
  136. Light — not pain-killing drugs — used to activate brain’s opioid receptors
    1. https://source.wustl.edu/2015/04/light-not-painkilling-drugs-used-to-activate-brain-opioid-receptors/
  137. Melatonin in Mitochondrial Dysfunction and Related Disorders
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100547/
  138. Blue light exacerbates and red light counteracts negative insults to retinal ganglion cells in situ and R28 cells in vitro
    1. https://pubmed.ncbi.nlm.nih.gov/30825600/
  139. The skin is a Solar powered battery ( Ted talk by Stephanie Seneff)
    1. https://www.youtube.com/watch?v=fDWEVXhaydc
  140. Where do we get our energy? – Nature commonly uses light to supply energy (pollack)
    1. https://www.youtube.com/watch?v=p9UC0chfXcg
  141. Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock
    1. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005886
  142. Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release
    1. https://www.pnas.org/content/114/38/E7997 
  143. Human-Centric Lighting: Foundational Considerations and a Five-Step Design Process
    1. https://www.frontiersin.org/articles/10.3389/fneur.2021.630553/full
  144. Can Extra Daytime Light Exposure Improve Well-Being and Sleep? A Pilot Study of Patients With Glaucoma
    1. https://www.frontiersin.org/articles/10.3389/fneur.2020.584479/full
  145. Sunlight Offers Surprise Benefit – It Energizes Infection Fighting T Cells
    1. https://gumc.georgetown.edu/news-release/sunlight-offers-surprise-benefit-it-energizes-infection-fighting-t-cells/
  146. Prolonged daily light exposure increases body fat mass through attenuation of brown adipose tissue activity
    1. https://www.pnas.org/content/112/21/6748.full
  147. Ultraviolet B Light Emitting Diodes (LEDs) Are More Efficient and Effective in Producing Vitamin D3 in Human Skin Compared to Natural Sunlight
    1. https://www.nature.com/articles/s41598-017-11362-2
  148. Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity
    1. https://www.pnas.org/content/118/1/e2018457118.long
  149. Bright light alters metabolism
    1. https://www.sciencedaily.com/releases/2016/05/160518141416.htm
  150. Infrared and skin: Friend or foe
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